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Nitric Oxide

Nitric oxide is a small, labile, lipid-permeable free radical molecule. It is synthesized from the amino acid l-arginine by NO synthase. When L-arginine is converted to nitric oxide, L-citrulline is produced as a by-product. L-citrulline can then be recycled back to L-arginine and used to increase your body’s natural production of nitric oxide.

Nitric oxide (NO) is very important in supporting mind- body wellness.

NO- Vasodilator:-

Nitric oxide is one of the most important molecules for your blood vessel health, being a vasodilator plays a very important role in transport of blood, oxygen & nutrients to different parts of the body, eliminates toxins that lead to muscle fatigue.

Nitric oxide is the ergogenic category of supplements that makes it best suitable for an endurance athlete, training at intermediate to advanced level.

How Nitric Oxide Came Into Existence For The Health Benefits

In 1980 Robert Furchgott investigated the role of a drug called acetylcholine on vasodilation and found that relaxation of blood vessels only occurred if a special class of cells called endothelial cells were present. Behind the endothelial cells are another specialised type of cell known as smooth muscle cells. The contraction and relaxation of these muscle cells is thought to be responsible for constricting or dilating the blood vessels.

Precursors Of Nitric Oxide: - L-Citrulline And L- Arginine

The main ingredients of nitric oxide supplements are arginine and citrulline. These two amino acids are known to be nitric oxide precursors of nitric oxide and therefore supplementing with arginine and citrulline can improve nitric oxide serum levels.

How Nitric Oxide Benefits Our Body: -

☞ Boost exercise, performance, recovery, and muscle gain: -

Nitric oxide reduces the amount of lactic acid produced during exercise and extends the amount of time until exhaustion. By speeding up the delivery of oxygen and nutrients to the muscles under stress, nitric oxide improves their response to exercise and so increases sports performance, which helps in recovery and muscle gain

☞ Regulates blood pressure: -

Nitric oxide being a vasodilator helps to relaxes the inner muscles of your blood vessels, causing the vessels to widen, which increases blood flow and lowers blood pressure.

☞ Supports cardiovascular health:

The arteries make nitric oxide to lower blood pressure and improve blood flow to organs because it is a vasodilator, which means it widens or relaxes the arteries so that more blood can flow through, therefore lowering the pressure within the arterial system

☞ Prevent blood clots

Nitric oxide as vasodilator- improves blood flow throughout the body which preventing clots

☞ Supports CNS: -

It is even a powerful neurotransmitter; it plays a key role in the switch between Sympathetic and Parasympathetic Nervous System responses.

NO provided provides analgesia (pain relief) and even lower blood pressure due to its vasodilatory properties

Boost your workouts or training with unique blends of Neulife Pre -workout boosters.Pre-Workout

Vasodilation is the state in which blood vessels are relaxed (dilated), leading to an expansion of their oxygen and nutrient carrying capacity. This leads to greater blood flow, better pumps and superior nutrient partitioning. Pre-workout science has moved on from its caffeine loaded days to a more holistic approach such as the one found in VASO-RAGE®.

PROCEL® VASO-RAGE® builds on our original VASO-X formula, which was specifically designed to cause large increases in Nitric Oxide (N.O) production. VASO-RAGE® additionally includes Nootropics, Cognition/Energy compounds and Adaptogens for an unparalleled pre-workout experience.

Benefits Of Pre-Workout

Increased Workout Performance and Efficiency
Get More Energy to Workout
Stimulate Metabolism
Recover Faster with Supplements
Improve Concentration and Focus

Types Of Pre-Workout

Pre-workouts can be divided into two groups:

☞Those with stimulants

They act as CNS stimulants and help improve mental focus. The stimulants pretty much always include caffeine, in widely varying doses, but may include other stimulants including yohimbine, theacrine , guarana, and many others

☞Those without stimulants

Many supplement companies have developed stimulant-free pre-workouts for those who are sensitive to caffeine, simply don't want it, or who exercise close to bedtime.

The main purpose of pre-workouts is to give you the energy, endurance, and focus to perform the exercises that can help you can reach of goal.Amino Acids

Branched chain amino acids (BCAAs) are a group of essential amino acids that comprise of 3 amino acids -Leucine, Isoleucine and Valine. They make up 35% of the total amino acid pool of the muscles. BCAAs do not go through the normal metabolic process as other aminos do, and instead reach directly to the muscles. They have a branched molecular structure that is easily broken down in the body to provide readily available energy to fuel exercise performance. Hence, they are crucial for an exercising individual.

The Role of (BCAAs)

BCAAs are in high demand during exercise, as they are rapidly used for energy. This reduces their availability for muscle repair, slowing or limiting the rate of muscle growth. After the BCAAs are used up, the body cannibalizes existing muscle tissue to obtain more BCAAs for energy use.

BCAAs Help To

Stimulate muscle protein synthesis
Prevent protein breakdown
Act as source of energy by getting metabolized in muscle
Delay fatigue and allow longer and harder workouts.
Regulate blood glucose levels
Reduce post-training muscle soreness

Whey Protein V/S A BCAA Supplement

One of the main reasons why whey protein is so effective for muscle growth and recovery is because it has a high BCAA content. However, exercise demands additional BCAAs to fulfill the dual demands of energy provision and protein synthesis. Inadequate BCAA levels post-training can lead to increased catabolism and decreased anabolism.

A stand-alone BCAA supplement, along with Whey protein, can safeguard the existing muscle tissue from being catabolized for energy as well as trigger the protein synthesis machinery efficiently. These free form BCAAs can be immediately utilized by the muscle tissue. As opposed to this, the BCAAs in Whey protein are present as peptide bonds and can be utilized after they are broken down to free form. Since this may take time, a stand-alone BCAA supplement is required to optimize anabolism post-training.

Which BCAA Ratio Is Better: 2:1:1 OR 8:1:1?

Leucine dominant BCAA formulations with Leucine: Isoleucine: Valine ratio as high as 8:1:1 are available to boost muscle protein synthesis. However, their potential to actually elevate protein synthesis is inconclusive.

A BCAA formulation providing Leucine: Isoleucine: Valine ratio of 2:1:1 is the most clinically studied ratio till date. And although Leucine is a major amino acid for triggering muscle growth, the other two BCAAs, Isoleucine and Valine also help in energy production and delaying fatigue. Isoleucine acts as a gluconeogenic amino acid and is converted into glucose, which helps maintain energy levels. Valine is reported to help in delaying perception of fatigue. Therefore, including these BCAAs in a ratio of 2:1:1 can provide optimum benefits.

A stand-alone BCAA supplement along with Whey protein can then safe-guard the existing muscle tissue from being catabolized for energy as well as trigger the protein synthesis machinery efficiently.

All the 3 BCAAs have different effects on metabolism. Amongst these, Leucine is a crucial amino acid for energy production and muscle protein synthesis. Leucine is the sole amino acid which triggers the protein synthesis pathway, an important step for muscle repair and growth.

BCAAs On A Low Carbohydrate Diet

A low carbohydrate diet is proven to be effective for the two most desired fitness goals - muscle building and fat loss. BCAAs become even more crucial amongst exercising individuals who are on a very low carbohydrate diet.

In such individuals they perform three separate functions – providing energy in the absence of glucose, providing an anti-catabolic effect through its protein sparing role and also causing enhanced protein synthesis (for enhanced protein synthesis, Leucine is the major contributor amongst the three). Hence it is anabolic as well as anti-catabolic.

Leucine – The Star BCAA

All 3 BCAAs have different effects on metabolism. Amongst these, Leucine is a crucial amino acid for energy production and muscle protein synthesis.

Leucine is the sole amino acid which triggers the protein synthesis pathway, an important step for muscle repair and growth. Weight training primes the body for muscle protein synthesis. However, this protein synthesis is not fully stimulated and skeletal muscle remains catabolic without supplemental dietary Leucine, either alone or as a part of protein or an amino acid mixture. Leucine, therefore, is important for the muscle for maximizing anabolism and recovery.

Researchers have reported that Increased leucine intake results in greater protein synthesis signaling and therefore leads to better lean mass gains.

Whey Protein Supplement With Added Leucine

It has been postulated that simply supplementing your whey protein with Leucine by itself also stimulates protein synthesis significantly. Research studies comparing leucine and whey protein’s ability in stimulating protein synthesis have reported that leucine, along with low-dose of whey protein, is able to stimulate protein synthesis similar to a larger dose of whey protein alone. A whey protein product containing additional leucine therefore will provide a higher anabolic boost.

Pre-Workout